Senior Global Project Manager (Sponsor-Dedicated, Remote – US) - Phase 1

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.  

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know: 

WORK HERE MATTERS EVERYWHERE

Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people. 
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives – we’re able to create a place where everyone feels like they belong. 

Job Responsibilities

Senior Global Project Manager (Sponsor-Dedicated, Remote – US)

About the Role

The Clinical Trial Leader (CTL), is a Senior Project Manager level role and serves as a key member of the sponsor’s Clinical Delivery Team, providing leadership, direction, and accountability across the full lifecycle of Phase II and III global clinical trials. This role ensures accurate planning, efficient execution, and delivery of trials that bring speed and value to participating subjects and sites.

Operating across multi-country, global studies, the CTL provides strategic and operational oversight to ensure trials meet their defined milestones and key performance indicators (KPIs). The successful candidate will demonstrate strong scientific and operational expertise, outstanding communication, and the ability to influence across complex matrix environments.

This is a sponsor-dedicated position supporting the experimental team worldwide, with therapeutic areas including Immunology. Candidates must have extensive Project Management experience in Phase I trials (additional TA experience is a plus), and a 4-year undergraduate degree.

What You Will Do:

Trial Preparation

• Lead planning and operational feasibility assessments to ensure realistic and achievable trial timelines.

• Oversee trial set-up and ensure team alignment across functions including Statistics, Data Management, Medical Writing, and Site Monitoring.

• Support country allocation and feasibility processes; provide input to optimize site selection and trial readiness.

• Develop and implement trial-level engagement, recruitment, and risk mitigation plans, integrating patient and site feedback to enhance trial design and participant experience.

• Coordinate outsourcing of vendor services, supporting vendor identification, selection, and scope-of-work development.

• Partner with cross-functional teams to ensure readiness across all trial processes — clinical quality, safety monitoring, investigational product management, budgeting, and site support.

• Facilitate and support responses to regulatory authorities, ethics committees, and other external stakeholders.

• Ensure all trial team members receive appropriate study-specific and standardized training.

Trial Conduct

• Maintain oversight of global clinical trial conduct to ensure compliance with Good Clinical Practice (GCP), internal SOPs, and all applicable regulatory requirements.

• Oversee patient recruitment progress, risk mitigation, and budget tracking to ensure efficient delivery.

• Manage amendments to study documentation and related retraining as needed.

• Ensure effective oversight of vendors and central labs, in collaboration with functional partners.

• Support ongoing communication and coordination across the clinical delivery network and stakeholders.

• For early-phase trials, coordinate activities related to biomarker sampling, genomics, and sub-studies.

Trial Closeout and Reporting

• Oversee data cleaning and trial closeout activities, ensuring timely and accurate data delivery.

• Support clinical trial report (CTR) generation and results disclosure to global registries.

• Ensure proper archiving of all essential documents within the Trial Master File (TMF).

• Support scientific publication of trial outcomes where applicable.

Strategic Contributions

• Contribute operational and scientific insight to trial and portfolio-level planning, supporting strategy alignment and risk mitigation.

• Ensure that key issues and insights are raised to the Evidence Team for timely resolution.

• Lead or support trial feasibility assessments that define critical design and execution parameters.

What You Will Bring:

Required

• Bachelor’s degree (4-year undergraduate degree) in a relevant field.

• Proven experience leading Phase I global clinical trials.

• Therapeutic area experience in Immunology (additional TA experience is a plus).

• Strong scientific and operational expertise across global clinical trial planning and execution.

• Exceptional leadership, communication, and stakeholder management skills in complex matrix structures.

• Ability to strategically plan and drive clinical trial delivery while ensuring patient-focused outcomes.

Core Competencies

• Leadership & Influence: Inspire and empower cross-functional teams to deliver results, providing vision and direction.

• Strategic Mindset: Forward-thinking, analytical, and innovative — able to navigate ambiguity and align trial strategy with portfolio objectives.

• Project Management Excellence: Translate complex challenges into actionable solutions, anticipate risks, and ensure transparent execution.

• Coordination & Oversight: Prioritize activities, manage resources efficiently, and ensure consistent trial progress globally.

• Strong Communication: Culturally aware, transparent communicator capable of aligning global teams and external stakeholders.

Why Join This Team:

This is more than a project management role — it’s an opportunity to shape the delivery of transformative therapies on a global scale. As a Senior Global Project Manager / Clinical Trial Leader, you will connect science, strategy, and execution, ensuring every trial advances efficiently, ethically, and with meaningful impact for patients worldwide.

At  Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time.  Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range:

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

http://www.syneoshealth.com

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive.  The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description.  The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above.   Further, nothing contained herein should be construed to create an employment contract.  Occasionally, required skills/experiences for jobs are expressed in brief terms.  Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees.  The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.

Required skills: Project Management, Vendor Management, GCP Required languages: English